Senior Scientist II

Posted on: 2010-05-15

Education

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                M.S. Chemistry Sept. 1998-July 2000

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                Furman University, Greenville SC

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                Research Advisor: Professor Timothy Hanks

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Thesis Topic: The Use of Charge-Transfer Interactions to Control the Solid-State Polymerization of Diacetylenes for the Construction of  Nanoporous Solids

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                B.S. Chemistry May 1998

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                Fairmont State College, Fairmont, WV

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Experience

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Irix Pharmaceuticals, Inc.  July 2000-July2008.  Synthetic Chemistry: Research and process development.  Compounds synthesized include:  imidates, amidines, piperidones, pyrimidines, imidazoles, piperazines, coumarins, aminothiazoles, enamines, indoles, and oxindoles

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Reactions done include: acetylations, halogenations, esterifications, nitrations, aminations, deaminations, amidations,                 reductions, oxidations, epoxidations, dehydrations, etc.  cGMP, cGLP experience, change control reports, deviation reports, raw material specs, pilot plant support, use test of raw materials, use test reports, communications with the client, analytical, QC, and QA, followed SOP’s.

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Furman University Fall 1998-The Use of Charge-Transfer Interactions to Control the Solid -State Polymerization of Diacetylenes for the Construction of Nanoporous Solids.  Multi-step synthesis of symmetrical and unsymmetrical diacetylenes containing  a donor.  Charge-Transfer  complexes were synthesized and photolyzed for the construction of nanoporous solids.

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Almaden Research Center Summer 1997 and 1998 Research Fellow- Charge Control Materials for Electrophoretic Displays.  Anion receptors were synthesized and binding was investigated with conductivity.

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Fairmont State College Fall 1997-Summer 1998- Independent research and study-The Multi-step synthesis of aza-crowns was undertaken as a joint project between IBM and Fairmont State College.  Anion Cages synthesized from the summer of 1997 were also studied with a variety of anions.

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Leadership skills

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                Fall 1997-Initiated a joint research project between Fairmont State College and IBM.

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                Sept. 1998-Teaching assistantship at Furman University

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                Summer of 1999-Supervised a student with her research at Furman University

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                July2000-2008-Independently led and produced multiple projects at IRIX Pharmaceuticals, Inc

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Instrumental Experience

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AA, 1H and 13C NMR, TGA, FTIR, UV-VIS, DSC, powder X-Ray diffraction, GC Mass Spec, HPLC, biotage, sp4 biotage

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Computer Experience

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Mathcad, Graphical Analysis, Excel, Multi-Purpose Lab Interface, Quattro Pro, Sci Finder and computational programs such as Spartan, Macspartan and CAChe

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Grant Writing Experience

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                A co-author of an ILI grant that was funded by NSF for an HP GC Mass Spec

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Awards

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                IBM/San Jose State University/NSF research award 1997

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                IBM/San Jose State University/NSF research award 1998

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                Coleman-Cobb-Postawa research award 1998

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                Nominated Freshman Writer of the Year

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                Manchesters Whos Who 2004

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                Promotion @ IRIX Pharmaceuticals, INC-Senior Scientist II-2004

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Presentations

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Regional ACS Meeting-Tennessee-October 1999-The Use of Charge-Transfer Interactions to Control the Solid-State Polymerization of Diacetylenes, Crihfield, A.; Phelps, D.; Hartwell, J.; Hanks, T.W.; Pennington, W.R; Bailey, R.D.

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National ACS National Meeting-New Orleans-August 1999-The Use of Charge-Transfer Interactions to Control the Solid-State Polymerization of Diacetylenes for the Construction of Nanoporous Solids, Crihfield, A; Phelps D.; Hartwell, J.; Hanks, T.W.; Pennington, W.R.; Bailey, R.D.

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                Almaden Research Center-poster session summer 1998-Charge-Control
                Agents for Electrophoretic Displays, April Crihfield and Sally Swanson

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Almaden Research Center-poster session summer 1997-Charge-Control Agents for Electrophoretic Displays, April Crihfield and Sally Swanson

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Publications

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                Synthesis of Polydiacetylene Charge-Transfer Complexes, Crihfield, A.; Phelps, D.;

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                Hartwell, J.; Hanks, T.W.; Pennington, WR.; Bailey, R.D. Mol. Cryst. and Liq. Cryst.

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Crystal Engineering through Halogen Bonding.  2.  Complexes of Diacetylene-Linked Heterocycles with Organic Iodides, Crihfield, A.; Hartwell, J.; Phelps D.; Bailey, R; Harris, J.; Payne, J.; Pennington, W; Hanks, T.W. Crystal Growth and Design.

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